Long-lived flies
Mutations that increase the life span of Caenorhabditis elegans encode components of the insulin/IGF signalling pathway. In the April 6 Science, two papers describe mutations that link insulin signaling with longevity in Drosophila melanogaster. Clancy et al. report that homozygous null mutations in chico, encoding an insulin receptor substrate protein, increased the female fly life span by up to 48% (Science 2001, 292:104-106). They were able to demonstrate that the effects of chico on longevit
Apr 9, 2001
Mutations that increase the life span of