Malaria mosquito resistance revealed
A G119S substitution in the acetylcholinesterase-1 gene confers insecticide resistance.
May 7, 2003
Malaria causes more than a million deaths a year in Africa alone. Attempts to combat the disease have been frustrated on two fronts: acquisition of resistance to antimalarial agents by the parasite itself and acquisition of resistance to insecticides by its mosquito vector,
Weill et al. compared the sequence of an organophosphate target (the acetylcholinesterase gene