Many mutant mice
In the August Nature Genetics , two groups report on their ongoing large-scale projects to produce mouse mutants using the chemical mutagen ethylnitrosourea. An English and French group have screened over 26,000 F1 progeny for dominant defects in growth and development, and a subset of these for defects in neural and behavioral function and blood chemistry (Nolan et al ., Nat. Genet . 2000, 25 :440-443). Their results are cataloged in Mutabase . Approximately half of the
Aug 9, 2000
In the August
The second effort, by Hrabe de Angelis