The microRNA miR-375 regulates myotrophin, a protein involved in the final stages of insulin secretion from pancreatic islet cells, according to a publication in
The results suggest miR-375 as a possible new avenue for diabetes treatment, according to lead author Markus Stoffel, from Rockefeller University in New York. Of possibly greater immediate significance is a growing belief that microRNAs play other important roles in the pancreas, he said.
"We took an unbiased approach and cloned all of the microRNAs from a pancreatic beta cell line," Stoffel told
To determine their functionality, the team overexpressed the microRNAs or inhibited endogenous microRNAs in beta cells and studied the effects on glucose-induced insulin secretion. miR-375 had a...