Stem cell transplantation in patients with leukaemia brings along donor immune cells that are the cause of graft-versus-host disease. But, the same cells can have a beneficial effect by eradicating residual malignant haematopoietic cells through the so-called graft-versus-leukaemia effect. In July
Working on irradiated leukaemic mice Fontaine
These findings suggest a single mechanism in the avoidance of graft-versus-host rejection and the potentiation of graft-versus-leukaemia effect and could have important implications for leukaemia immunotherapy.