Modulation by matrix
Interactions of cells with the extracellular matrix (ECM), via the integrin receptors, modulate cell proliferation, survival and differentiation. In the April 10 Proceedings of the National Academy of Sciences, Yarwood and Woodgett describe how the make up of the ECM can affect the cellular response to growth-factor stimulation (Proc Natl Acad Sci USA 2001, 98:4472-4477). They used cDNA microarrays to analyse over 1,718 human genes and measure changes in gene expression when cells were plated on
Apr 8, 2001
Interactions of cells with the extracellular matrix (ECM), via the integrin receptors, modulate cell proliferation, survival and differentiation. In the April 10