MODY-fying gene expression in diabetes
Identification of genes that are regulated by the transcription factor HNF1alpha may explain its involvement in MODY3 diabetes.
Sep 12, 2000
HNF1α (hepatocyte nuclear factor 1) was originally isolated as a liver transcription factor. So it came as a sweet surprise to researchers when HNF1α was identified as the gene mutated in patients suffering from MODY3, maturity onset diabetes of the young subtype 3. As they report in the 15 August