Molecules affecting atherosclerotic disease progression
VCAM-1 has a dominant role in initiation of atherosclerosis but macrophage MMP-1 activity seems to limit the progression of disease.
Jun 4, 2001
In May 15
Cybulsky
They manipulated the Ig domain and obtained a VCAM-1 deficient mouse. When fed on a cholesterol-enriched diet, mice VCAM-1 deficient showed a reduced area of early atherosclerotic lesions in the aorta, although cholesterol levels, lipoprotein profiles and numbers of circulating leukocytes were comparable to wild-type. In contrast, deficiency of ICAM-1 either alone or in combination with VCAM-1 did not alter lesion formation (
In a second paper, Lemaître