More protection against anthrax
The main virulence factor of Bacillus anthracis is a toxin that consists of three separate gene products; protective antigen (PA), lethal factor (LF) and edema factor (EF). In July Infection and Immunity, Brian Price and colleagues from Ohio State University showed that DNA-based immunization with a plasmid encoding the LF or PA protein provides complete protection against anthrax lethal toxin.Price et al. used a gene gun to inoculate mice with either a vector plasmid encoding a fragment of PA o
Oct 15, 2001
The main virulence factor of
Price
These results suggest that it is feasible to use a DNA-based immunization strategy against anthrax and any future anthrax vaccine should consider...