Mouse mutagenesis
Large-scale mutagenesis projects using the chemical mutagen ethylnitrosurea (ENU) are being developed to help with the functional annotation of the mouse genome. In an Advanced Online Publication in Nature Genetics, Emma Coghill and colleagues describe a gene-driven approach to find mutant mice (Nat Genet 2002, DOI:10.1038/ng847).Coghill et al. screened over 2,000 samples contained within an archive of DNA and sperm from the UK ENU mutagenesis program. They screened the archives for four genes u
Feb 25, 2002
Large-scale mutagenesis projects using the chemical mutagen ethylnitrosurea (ENU) are being developed to help with the functional annotation of the mouse genome. In an Advanced Online Publication in
Coghill
The team were able to isolate three mutations (one missense and one stop mutation) within the
Coghill