Mutation in Cd36 gene protects from malaria
Erythrocytes infected with Plasmodium falciparum adhere to host CD36 receptors expressed on endothelial cells, platelets and leucocytes. This process is thought to benefit parasite survival in malaria. In the 12 May Lancet, Arnab Pain and colleagues from the Institute of Molecular Medicine in Oxford, UK report a mutation in the Cd36 gene that is associated with protection from severe malaria.Pain et al sequenced DNA from two Afro-Americans who did not express CD36 on their platelets and identifi
May 13, 2001
Erythrocytes infected with
Pain
The mutation may influence the expression of CD36 on the endothelium and reduce...