Natural remedy for vision loss
Pathological angiogenesis can cause loss of vision and is associated with many diseases of the eye for which there exists no effective treatment. In January 8 Proceedings of the National Academy of Sciences, two papers by teams from The Scripps Research Institute, La Jolla, USA, described the unexpected antiangiogenic activity of a fragment of the human protein tryptophanyl-tRNA synthetase (TrpRS), a molecule also known to be involved in protein synthesis and cell proliferation. Atsushi Otani an
Jan 9, 2002
Pathological angiogenesis can cause loss of vision and is associated with many diseases of the eye for which there exists no effective treatment. In January 8
Atsushi Otani and colleagues observed that a recombinant fragment of TrpRS is a potent antagonist of vascular endothelial growth factor-induced angiogenesis in a murine model. The effect was also confirmed in naturally occurring retinal angiogenesis in the neonatal mouse (
In a second study Wakasugi