Negative regulator of B cell function
A newly identified Btk-interacting protein, IBtk, binds to the PH domain of Btk and downregulates Btk function in B cells.
Sep 26, 2001
Bruton's tyrosine kinase (Btk) critical for lymphocyte B cell survival but if unchecked, can result in immunodeficiency of the development of cancer. In October
Working with yeast plasmids and T cells, Liu
The authors suggests that the discovery of IBtk may lead to a better understanding of the clinical heterogeneity in human X-linked agammaglobulinemia, which is characterized by genetic mutations in the Btk-PH domain.