Novel breast cancer suppressor gene
DBC2 is a new candidate for a tumor suppressor gene involved in breast cancer.
Oct 8, 2002
Numerous tumor suppressor genes — including PTEN and p53 — are down regulated in sporadic breast cancer but the molecular basis of cancer development remains incompletely understood. In the Early Edition of
Hamaguchi et al. analyzed breast cancer biopsies by representational difference analysis (RDA). They observed that an RDA probe detecting homozygous deletion mapped to human chromosome 8p21, and that DBC2 is the best candidate tumor suppressor gene from this region. DBC2 expression in breast cancer cells lacking DBC2 caused growth inhibition. In addition, they observed that DBC2 derived from breast tumor specimens contain somatic missense mutations.
"All these data...