Nuclear reprogramming in cloned cows
Telomere length shortens upon culture of fibroblast cells in vitro. But what happens to chromosomal ends and telomerase activity when nuclei from these aged cells are used to clone animals by somatic nuclear transfer? In the January 30 Proceedings of the National Academy of Science Betts et al. report on telomeres and telomerase activity in early and late-passage donor fibroblasts and recipient cloned bovine embryos (Proc Natl Acad Sci USA 2001, 98:1077-1082). Despite the reduction in telomere l
Feb 6, 2001
Telomere length shortens upon culture of fibroblast cells