Nucleating autoimmunity
An IgG/DNA complex activates B cells and provokes autoimmune responses.
Apr 11, 2002
Autoimmune diseases are frequently caused by abnormal production of self-antibodies but the mechanisms responsible for generating B cell autoreactivity remain unclear. In April 11
Leadbetter
"These data establish a critical link between the innate and adaptive immune systems in the development of systemic autoimmune disease and explain the preponderance of autoantibodies reactive with nucleic acid–protein particles," said the authors.
In addition, "drugs that specifically target Toll-like receptor signaling...