Oncogenic phosphatase amplification
Post-translational regulation of p53 regulates its activity and tumor suppressor functions. In an Advanced Online Publication in Nature Genetics, Dmitry Bulavin and colleagues from the National Institutes of Health describe how oncogenic Ras regulates p53 phosphorylation (Nat Genet 2002, DOI:10.1038/ng894).Bulavin et al. used antibodies specific for different modified forms of p53 and showed that oncogenic Ras induced p53, accumulation and phosphorylation of two specific serine residues that are
May 26, 2002
Post-translational regulation of p53 regulates its activity and tumor suppressor functions. In an Advanced Online Publication in
Bulavin
An accompanying report by Jing Li and colleagues provides additional evidence for
These results suggest...