p53 mysteries
No one really understands why activation of the tumor suppressor p53 sometimes leads to cell-cycle arrest and sometimes induces an apoptotic program. It has been proposed that post-translational modifications (phosphorylation and acetylation) induced by genotoxic stress affect the DNA binding affinity of p53. In the January 8 issue of Proceedings of the National Academy of Sciences, Kaeser and Iggo suggest that such models should be reassessed in light of their results using chromatin immunoprec
Jan 14, 2002
No one really understands why activation of the tumor suppressor p53 sometimes leads to cell-cycle arrest and sometimes induces an apoptotic program. It has been proposed that post-translational modifications (phosphorylation and acetylation) induced by genotoxic stress affect the DNA binding affinity of p53. In the January 8 issue of
To test p53 binding