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Peeking into cytokinesis

Blebbistatin could help dissect the final stages of cell division.

Andrea Rinaldi(rinaldi@unica.it)

Cytokinesis — the final stage in eukaryotic cell division — is achieved by the constriction of an actomyosin-based contractile ring and its associated plasma membrane, partitioning the cytoplasm into the daughter cells. The process is complete within a few minutes and is tightly regulated in space and time, but the exact mechanisms by which the cell cycle machinery regulates the contractile ring and the microtubules associated with the mitotic apparatus has been unclear. In the March 14 Science, Aaron Straight and colleagues at the Harvard Medical School, Boston, US, reported the discovery of a compound called blebbistatin that holds significant promise as a tool to understand how cytokinesis is regulated (Science, 299:1743-1747, March 14, 2003).

Straight et al. investigated the signals used in mammalian cells to communicate between the microtubule cytoskeleton, the actin cytoskeleton and the cell membrane, to identify a molecule that could inhibit contraction...

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