Phosphatase in metastasis
Metastasis poses the greatest threat to the survival of cancer patients, yet the molecular events underlying this complex process are unclear. In the October 11 ScienceXpress, Saurabh Saha and colleagues at the Johns Hopkins Medical Institutions, Baltimore, USA, describe serial analysis of gene expression (SAGE) to identify genes involved in liver metastasis in colorectal cancer patients (ScienceXpress 10.1126/science.1065817).They developed an immunoaffinity fractionation procedure to purify co
Oct 15, 2001
Metastasis poses the greatest threat to the survival of cancer patients, yet the molecular events underlying this complex process are unclear. In the October 11
They developed an immunoaffinity fractionation procedure to purify colorectal epithelial cells away from contaminating hepatic cells. They then analysed 95,000 tags, representing over 17,000 transcripts, and identified 144 transcripts upregulated in metastatic cells. Experimental verification showed that one gene,