plays a pivotal role in pulmonary fibrosis
Pulmonary fibrosis is considered a deleterious consequence of persistent lung inflammation, but the mechanism by which inflammation leads to fibrosis remains incompletely understood. In June 15 Journal of Clinical Investigation, Martin Kolb and colleagues from McMaster University, Ontario, Canada, show how acute tissue injury in the lung — initiated by a highly proinflammatory cytokine — IL-1β, converts to progressive fibrotic changes.Kolb et al. used adenoviral gene transfer to
Jun 19, 2001
Pulmonary fibrosis is considered a deleterious consequence of persistent lung inflammation, but the mechanism by which inflammation leads to fibrosis remains incompletely understood. In June 15
Kolb
These findings suggest that IL-1β plays a pivotal role in the induction of fibrosis and may be a target for...