Prohibitin genotyping as breast cancer indicator
The 3' untranslated region of the prohibitin gene encodes an RNA molecule that arrests cell proliferation when injected into breast cancer cell lines. A single point mutation in this region creates a variant T allele that lacks the antiproliferative activity of the more common functional C allele. In May 19 Lancet, Eldon Jupe and colleagues from Oklahoma Medical Research Foundation, Oklahoma City present evidence that women carrying the prohibitin T allele have increased susceptibility to breast
May 20, 2001
The 3' untranslated region of the prohibitin gene encodes an RNA molecule that arrests cell proliferation when injected into breast cancer cell lines. A single point mutation in this region creates a variant T allele that lacks the antiproliferative activity of the more common functional C allele. In May 19
Jupe