Prostaglandin's colon repair receptor
Nonsteroidal anti-inflammatory drugs increase the severity of human inflammatory bowel disease (IBD), but little is known about the mechanisms by which prostanoid inhibition modulates IBD. In April 1 Journal of Clinical Investigation, Kenji Kabashima and colleagues from Kyoto University, Kyoto, Japan, show that the prostaglandin receptor EP4 has a key role in mucosal protection, suppressing colitis, mucosal damage and CD4 cell activation in the gut.Kabashima et al. examined mice deficient in pro
Apr 2, 2002
Nonsteroidal anti-inflammatory drugs increase the severity of human inflammatory bowel disease (IBD), but little is known about the mechanisms by which prostanoid inhibition modulates IBD. In April 1
Kabashima