Pseudomonas switch to resistance
Pseudomonas aeruginosa grows as biofilms in the lungs of patients with cystic fibrosis (CF) but it remains unclear if the bacteria persist because the biofilms are antibiotic-resistant or if resistant variants are selected by antimicrobial therapy itself. In April 18 Nature, Eliana Drenkard and Frederick Ausubel of Harvard Medical School show that Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation and are switched on together.Drenkard & Ausubel observe
Apr 18, 2002
Drenkard & Ausubel observed that antibiotic resistant phenotypic variants of
"Drenkard and Ausubel have described a general mechanism — environment driven phenotypic switching — that explains how antibiotic-resistant biofilm variants of