RAGE against arthritis
RAGE (receptor for advanced glycation end-products) and its proinflammatory ligands are commonly identified in the joints of patients with rheumatoid arthritis (RA), but their role in the disease has been unclear. In May Genes and Immunity, Hofmann and colleagues from Columbia University, New York, show that a polymorphism in the RAGE gene within the ligand-binding domain of the receptor (RAGE 82S) may contribute to enhanced proinflammatory mechanisms in immune/inflammatory diseases (Genes Immun
May 27, 2002
RAGE (receptor for advanced glycation end-products) and its proinflammatory ligands are commonly identified in the joints of patients with rheumatoid arthritis (RA), but their role in the disease has been unclear. In May
Hofmann