Regulating p53
MDM2 is an E3 ubiquitin ligase that regulates the activity of p53 by controlling degradation of the p53 protein, as a result of differential addition of ubiquitin. In the Advanced Online Publication of Nature Genetics, Parant et al. report the phenotype of mice lacking the recently cloned MDM2-related protein MDM4 (DOI:10.1038/ng714).They show that mdm4-null mice die at embryonic day 7.5-8.5. Analysis of the incorporation of the nucleotide analogue BrdU and TUNEL staining for apoptotic cells sho
Aug 28, 2001
MDM2 is an E3 ubiquitin ligase that regulates the activity of p53 by controlling degradation of the p53 protein, as a result of differential addition of ubiquitin. In the Advanced Online Publication of
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