The response of cells to telomere loss is thought to resemble the DNA damage response. In the Early Edition of the Proceedings of the National Academy of Sciences, Shivani Nautiyal and colleagues describe genome-wide gene expression changes upon deletion of
The coin the term 'telomerase deletion response' (TDR) to refer to the transcriptional program induced by telomere shortening. The TDR overlaps with the DNA damage response and the environmental stress response. Nautiyal
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