Ribozyme targeting
In the March 19 Proceedings of the National Academy of Sciences, Mohammed Kashani-Sabet and colleagues describe the use of plasmid-based ribozymes as functional genomics tools to unravel complex phenotypes, such as cancer metastasis (Proc Natl Acad Sci USA 2002, 99:3878-3883).Kashani-Sabet et al. reasoned that ribozyme-based gene targeting in mice might overcome experimental problems associated with transgenesis and lethal knockout phenotypes. They tested the use of systemic administration of ca
Mar 20, 2002
In the March 19
Kashani-Sabet