Rofecoxib and osteoarthritis
NEW YORK, June 27 (Praxis Press) Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) but it is unclear whether specific COX-2 inhibitors are as effective as NSAIDs in the treatment of osteoarthritis (OA). Day and colleagues compared the efficacy and safety of the rofecoxib, which specifically inhibits COX-2, with that of the NSAID ibuprofen in 809 adult patients with OA (see paper. They found that rofecoxib was as effective as ibuprofe
The Scientist Staff
Jun 26, 2000
NEW YORK, June 27 (