Seven up

The complete chromosome 7 sequence enables identification of candidate genes for autism.

Jonathan Weitzman(
Apr 13, 2003

In the April 10 Sciencexpress, Stephen Scherer and colleagues report completion of the sequencing and annotation of human chromosome 7. The sequence is 158 megabases long, most of which comes from the Celera whole-genome scaffolds, combined with the public clone-based sequence (Sciencexpress, DOI:10.1126/science.1083423, April 10, 2003).

Scherer et al. integrated the chromosome 7 sequence with data from a number of database resources, particularly those related to human disease. Comparative analysis revealed a relatively small number of discrepancies with the NCBI chromosome 7 assembly. Comparison with the Celera mouse genome sequence led to the identification of around 22,000 syntenic anchor points. They identified 1917 gene structures, almost half of which correspond to known genes, with an average gene size of around 70 kb. There are 99 overlapping genes and 38 sense-antisense gene pairs and there is evidence for extensive intra-chromosomal duplications, some of which coincide with mouse synteny...

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