Silencing splicing
Many sequences found within mammalian introns closely resemble the specific 5' and 3' splice site consensus signals that regulate exon splicing. It is unclear how the real splice sites are selected from these frequent pseudosites. In the September Molecular and Cellular Biology, Fairbrother and Chasin identified intronic splicing silencers using a genetic screen (Mol Cell Biol 2000, 20:6816-6825). They selected human genomic sequences that could disrupt splicing when inserted into the central ex
Sep 26, 2000
Many sequences found within mammalian introns closely resemble the specific 5' and 3' splice site consensus signals that regulate exon splicing. It is unclear how the real splice sites are selected from these frequent pseudosites. In the September