Splicing chips
The process of RNA splicing by the spliceosome helps to generate molecular diversity beyond the genome sequence. In the May 3 Science, Tyson Clark and colleagues at the University of California, Santa Cruz describe a genome-wide study of splicing in yeast (Science 2002, 296:907-910).Clark et al. designed custom microarrays with oligonucleotides capable of distinguishing between spliced and unspliced RNAs, and demonstrated the specificity of this splicing-specific microarray by analysing RNA from
May 6, 2002
The process of RNA splicing by the spliceosome helps to generate molecular diversity beyond the genome sequence. In the May 3
Clark
This strategy will could be applied to the human genome in which as many as 60%...