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controls capsaicin receptor thermal and chemical sensitivity
May 22, 2003
Tissue injury generates endogenous factors that heighten the perception of pain by increasing the response of sensory nerve endings to noxious stimuli. In this process, the capsaicin receptor (TRPV1) is sensitized by phosphatidylinositol-4,5-bisphosphate (PIP2) hydrolysis following phospholipase C activation, but the mechanism that controls capsaicin receptor sensitization has been unclear. In the May 23
The researchers measured continuous current traces in mutated