Structure of a DNA damage repair protein
The Ku heterodimer forms a cradle in which broken DNA strands rest whilst being repaired.
Aug 8, 2001
Damage to DNA strands resulting in breakage can lead to chromosomal translocation, uncontrolled cellular growth and cancer. These breaks can occur following exposure to agents such as ionizing radiation, or in programmed events such as gene shuffling. In mammalian cells this damage is repaired by a family of proteins involved in non-homologous end joining (NHEJ).
In August 9
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