Switching on angiogenesis
The growth of actively proliferating tumors requires the initiation of new blood vessel production by an unknown trigger, often referred to as the 'angiogenic switch'. In January 22 Proceedings of the National Academy of Sciences, Jack Arbiser and colleagues from Emory University School of Medicine, Atlanta, US show that reactive oxygen generated by Nox1 is an important trigger of angiogenesis.Arbiser et al. found that vascular endothelial growth factor (VEGF) mRNA becomes markedly up regulated
Jan 22, 2002
The growth of actively proliferating tumors requires the initiation of new blood vessel production by an unknown trigger, often referred to as the 'angiogenic switch'. In January 22
Arbiser
"These findings point for the first time to uncontrolled generation of reactive oxygen and to Nox enzymes as a possible cause in the progression...