T-cell loss in HIV explained

not a decrease in T cell production.

Tudor Toma(t.toma@ic.ac.uk)
Dec 11, 2001

It has been widely held that HIV depletes its primary target, CD4+ T cells, by blocking new T-cell production. But two independent studies published in December 17 and November 5 of Journal of Experimental Medicine show now that HIV does not block such production, but instead accelerates the division of existing T cells.

Joseph Kovacs and colleagues from National Institutes of Health, Bethesda, US examined, in vivo the effects of HIV on the turnover of CD4+ and CD8+ T cells in infected patients. They found that the viral load affects only the size of a rapidly proliferating pool of both CD4 and CD8 T cells with no effect on the slowly proliferating T cells. In addition, HAART (Highly Active Anti-Retroviral Therapy) decreased just the size of the rapidly proliferating T cells (J Exp Med 2001, 194:1731-1741).

These results confirm findings in a study by...

Interested in reading more?

Become a Member of

Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?