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The aptness of aptamers

RNA aptamers can be used to create antidote-controlled anticoagulant agents.

Jonathan Weitzman(jonathanweitzman@hotmail.com)

Aptamers are nucleic acid ligands selected to interact with specific proteins with high affinity. In the 5 September Nature, Christopher Rusconi and colleagues describe the elegant design of a drug-antidote pair to control blood clotting using aptamer technology (Nature 2002, 419:90-94).

Rusconi et al. screened a nucleic-acid combinatorial library for aptamers specific for coagulation factor FIXa. They selected a high-affinity aptamer and demonstrated that it could inhibit FIXa activity and acted as an anti-coagulant. They also created antidote oligonucleotides that blocked binding of the aptamer. The drug and antidote could effectively control clotting times in the plasma of patients with heparin-induced thrombocytopenia.

This strategy presents a promising approach for the development of safe aptamer-antidote pairs as therapeutics.

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