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The Best Multimedia of 2017

Editors’ picks of the year’s best in The Scientist infographics.

Dec 27, 2017
Catherine Offord

Gene drives to combat malaria

A gene drive can be designed to disrupt a mosquito gene essential for survival or reproduction. Researchers restrict its expression to the germline, such that individuals that have one copy of the inserted genetic element (the gene drive) still have a functioning copy of the mosquito gene in the rest of their bodies where it is needed. Through the germline, the gene drive spreads, increasing the proportion of gametes that carry it. When two mosquitoes carrying the gene drive mate, none of their offspring would inherit a functional copy of the essential gene, decimating the population.

THE SCIENTIST STAFF

Forces in the cell

Physical forces generated outside a cell can be transmitted to the cytoskeleton via cell-surface receptors known as integrins and associated protein complexes called focal adhesions. Once believed to act over only short distances, such forces are now recognized to propagate tens of microns across cells via cytoskeletal filaments such as actin stress fibers and microtubules.

© THOM GRAVES

Plastic pollution

Plastics enter the environment from many sources such as accidental losses during waste collection and from landfills, general littering, runoffs, and waste processing.

© AL GRANBERG. SOURCE: NATURE, 537:488, 2016; SCIENCE, 347:768-71, 2015

Immune irritation in celiac disease

In the small intestine, gluten proteins are broken down into their component glutenins and prolamins. In celiac patients, the subsequent responses cause considerable atrophy of the intestinal villi—projections of the small intestinal wall that facilitate efficient absorption of nutrients. 

© JULIA MOORE

A cycle of methylation

Recent research has revealed that the DNA base cytosine can be modified into a number of variants. Scientists are still hunting for the functions of these modifications, but evidence points to their roles in gene regulation and DNA integrity, affecting learning and memory.


THE SCIENTIST STAFF

 

Writing with DNA

Researchers are developing methods to store humanitys burgeoning volume of data in DNA by converting text or sequences of binary digits into the language of A, C, G, and T.

THE SCIENTIST STAFF. SOURCE: SCIENCE, 293:1763-65, 2001; SCIENCE, 337:1628-29, 2012; NATURE, 494:77-80, 2013. 

 

September 2018

The Muscle Issue

The dynamic tissue reveals its secrets

Marketplace

Sponsored Product Updates

Horizon Discovery introduces Myeloid DNA Reference Standard to support genetic testing of leukemia

Horizon Discovery introduces Myeloid DNA Reference Standard to support genetic testing of leukemia

Horizon Discovery Group plc, a global leader in gene editing and gene modulation technologies, today announced the launch of its Myeloid DNA Reference Standard. The first-to-market large cell-line derived myeloid cancer reference standard designed enables faster, more reliable and more cost-effective assay validation, to support the market in bringing routine testing into practice.

StemExpress LeukopakâNow Available in Frozen Format

StemExpress LeukopakâNow Available in Frozen Format

StemExpress, a Folsom, California based leading supplier of human biospecimens, announces the release of frozen Peripheral Blood Leukopaks. Leukopaks provide an enriched source of peripheral blood mononuclear cells (PBMCs) with low granulocyte and red blood cells that can be used in a variety of downstream cell-based applications.

New Antifade Mounting Media from Vector Laboratories Enhances Immunofluorescence Applications

New Antifade Mounting Media from Vector Laboratories Enhances Immunofluorescence Applications

Vector Laboratories, a leader in the development and manufacture of labeling and detection reagents for biomedical research, introduces VECTASHIELD® Vibrance™ – antifade mounting media that delivers significant improvements to the immunofluorescence workflow.

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Download this white paper from Bertin Technologies to learn how to extract and analyze lipid samples from various models!