Guesses about the number of genes in the human genome vary wildly and may continue to do so even when the entire genome sequence is available. Computational methods for picking out exons that are scattered amongst vast introns yield both false positives and false negatives. This has prompted a Brazilian sequencing group to generate a quarter of a million open reading frame (ORF) expressed sequence tags (ORESTES), as they report in the November 7
William Wells(wells@biotext.com)