The genetic mechanisms that contribute to the development of cardiovascular disease have been largely unknown. In 20 June
Crackower
In addition, they generated ACE2 knockout mice and observed impaired contractility, increased angiotensin II levels and upregulated hypoxia-induced genes in the heart. Genetic ablation of ACE on an ACE2 mutant background completely rescued the cardiac phenotype. But ACER (a
"The paper by Crackower