The real culprit in Graves disease
Thyroid-stimulating autoantibodies preferentially recognize the free A subunit, not the thyrotropin holoreceptor, in Graves thyrotoxicosis.
Jul 23, 2002
In Graves disease, thyroid-stimulating autoantibodies activate the thyrotropin receptor (TSHR), leading to increased thyroid hormone secretion and clinical thyrotoxicosis, but the exact molecular interactions are not know. In 15 July
Chazenbalk
These results "provide evidence that TSAb's in Graves disease preferentially recognize the free A subunit and not the TSH holoreceptor," concluded the authors. "This...