The role of complement in spongiform encephalopathies
Depletion of complement factors or the complement receptor significantly delays the onset of scrapies in a mouse model.
Apr 2, 2001
Agents of transmissible spongiform encephalopathies (TSEs) usually enter the body via a peripheral route and replicate in lymphoreticular tissues before moving into the brain. Any impairment of the lymphoreticular system slows transfer of the TSE agent to the brain and delays the clinical onset of symptoms. In the April
In the two independent studies on mouse models of scrapie Klein