Towards better TB vaccines
Recombinant BCG exporting ESAT-6 may increase protection against tuberculosis.
Apr 13, 2003
The BCG (bacille Calmette-Guérin) tuberculosis vaccine derived from
Pym et al. created numerous BCG constructs containing the esxA and esxB genes, which encode ESAT-6 and CFP-10 respectively, and a variable number of flanking genes. They observed that only reintroduction of the complete RD1 locus, comprising...