Transgene switch
The ability to regulate transgene expression levels is essential for many functional genomic and therapeutic applications. In an Advanced Online Publication in Nature Biotechnology, Wilfried Weber and colleagues describe the development of E.REX, a novel gene regulation system that exploits components of the Escherichia coli erythromycin-resistance regulon (Nat Biotechnol 2002, DOI:10.1038/nbt731).They designed both EOFF and EON systems that are respectively repressed or induced using macrolide
Aug 20, 2002
The ability to regulate transgene expression levels is essential for many functional genomic and therapeutic applications. In an Advanced Online Publication in
They designed both EOFF and EON systems that are respectively repressed or induced using macrolide antibiotics (including erythromycin, clarithromycin and roxithromycin). Weber