Trypsin protection
The Paneth cells (secretory epithelial cells) of the human small intestine protect against pathogenic microbial infection through the release of antibiotic polypeptides, such as defensins, but the precise identity of the mediators involved in this process remains unclear. In May 20 Nature Immunology, Dipankar Ghosh and colleagues from The Cleveland Clinic Foundation, Ohio, show that the trypsin of Paneth cells is the enzyme responsible for processing human defensin-5 (HD5), stored as a propeptid
May 19, 2002
The Paneth cells (secretory epithelial cells) of the human small intestine protect against pathogenic microbial infection through the release of antibiotic polypeptides, such as defensins, but the precise identity of the mediators involved in this process remains unclear. In May 20
Gosh
"By acting as a prodefensin convertase, and perhaps through signaling effects, trypsin released from Paneth...