Laboratory animals can be trained to perform simple tasks in response to external cues (such as specific noises) or rewards (such as food). In the May 2 Nature, Sanjiv Talwar and colleagues describe a learning procedure based on brain microstimulation rather than external cues (Nature 2002, 417:37-38).

Talwar et al. implanted stimulating electrodes in the medial forebrain bundle (MFB) or the somatosensory cortical, to mimic rewards or cues, respectively. They strapped a remote-control microstimulator backpack to each animal. In this way the operator could train the rats from as much as 500 m away by delivering stimulus pulses. MFB stimuli were used to drive forward locomotion and could guide the rats through pipes and around mazes.

The authors propose that such 'virtual' learning methods provide a powerful tool to and understanding of the neurophysiology of learning and behavior. They add that this approach "could allow a...