Ultraviolet sensitivity
The systematic deletion of all yeast ORFs, the Saccharomyces Genome Deletion Project, provides a powerful resource for large-scale 'parallel deletion analysis'. In the October 23 Proceedings of the National Academy of Sciences, Geoff Birrell and colleagues at Stanford University School of Medicine describe a screen for sensitivity to a genome-damaging agent (Proc Natl Acad Sci USA 2001, 98:12608-12613).They screened pools of 4,627 deletion strains for killing by ultraviolet (UV) irradiation and
Oct 21, 2001
The systematic deletion of all yeast ORFs, the Saccharomyces Genome Deletion Project, provides a powerful resource for large-scale 'parallel deletion analysis'. In the October 23
They screened pools of 4,627 deletion strains for killing by ultraviolet (UV) irradiation and used oligonucleotide arrays to follow radiation sensitivity. They identified 25 known UV-sensitive deletions and found three new genes not previously linked with UV sensitivity. Two of these,