Vesicle age regulates exocytosis
Younger vesicles are preferentially selected to release their contents.
Mar 12, 2003
The release of peptide hormones or neurotransmitters from neuroendocrine cells is essential for the co-ordination of diverse physiological events. Secretory vesicles derived from the trans-Golgi undergo a complex cycle — including maturation, translocation, membrane docking, and fusion of a subpopulation of vesicles with the cell membrane — but many aspects of vesicle dynamics are still unclear. In the March 13
Duncan et al. developed a system to track fluorescently labeled large dense-core secretory vesicles (LDCVs) in living, cultured bovine adrenal chromaffin cells (BCCs). Fluorescent labeling of LDCVs was achieved by transduction of BCCs so as to express the...