Why some don't get emphysema
finds that Nrf2 protects against inflammation and destruction of lungs
Nov 2, 2004
Nrf2—a protein involved in protecting against oxidative stress—is critical in the protection of the lungs in mice against the inflammation and destruction typical of emphysema, a team of researchers at Johns Hopkins University Bloomberg School of Public Health report in the November 1 issue of the
Biswal and colleagues subjected Nrf2-deficient mice as well as wildtype ICR strain mice to chronic cigarette smoke by burning cigarettes using a smoking machine. The authors found a dramatic increase in alveolar destruction in the lungs of Nrf2-deficient mice when compared with wildtype mice after...