The anatomical distribution of pathological changes in the brain in early stages of Alzheimer's disease is selective for the endorhinal cortex of the ventromedial temporal lobe and the hippocampal formation, known to be important for long-term memory. Progress on understanding the pathophysiology of Alzheimer's disease could lead to a better understanding of memory mechanisms as well as treatments.

G.W. Van Hoesen, B.T. Hyman, A.R. Damasio, "Entorhinal cortex pathology in Alzheimer's disease," Hippocampus, 1, 1-8, January 1991. (University of Iowa School of Medicine, Iowa City; Massachusetts General Hospital, Boston; Harvard Medical School, Boston)

One of the major discoveries in auditory physiology is that the basilar membrane in the cochlea is not a passive mechanical system but an active filter that can be adjusted according to the auditory input. A report identifies the nature of the motor element in the cochlear outer hair cell that controls its shape.

P. Dallos, B.N. Evans,...

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